Heightened CXCR4 and CXCL12 expression in NF1-associated neurofibromas

KARAOSMANOĞLU B., Kocaefe C. Y., Soylemezoglu F., Anlar B., VARAN A., VARGEL İ., ...More

CHILDS NERVOUS SYSTEM, vol.34, no.5, pp.877-882, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1007/s00381-018-3745-6
  • Journal Name: CHILDS NERVOUS SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.877-882
  • Hacettepe University Affiliated: Yes

Abstract

Neurofibromatosis type 1 (NF1) is a common autosomal dominantly inherited disorder that affects both the skin and the nervous system. NF1 occurs due to the mutations in the NF1 gene. Neurofibromas are the most common Schwann cell-based tumors in NF1 patients, which are mainly categorized into dermal and plexiform neurofibromas. Studies on different tumor types demonstrate that CXCR4 expression increases in tumor tissues and is linked to metastasis and cancer progression.