The expression of BMP, integrin, ZEB2 in ovarian high-grade serous carcinoma in relation with lymph node metastasis


Zirh E. B. , Kapakli E. T. , Dolgun A., USUBÜTÜN A., ZEYBEK N. D.

GROWTH FACTORS, vol.40, no.3-4, pp.153-162, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3-4
  • Publication Date: 2022
  • Doi Number: 10.1080/08977194.2022.2099849
  • Journal Name: GROWTH FACTORS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.153-162
  • Keywords: High-grade ovarian cancer, lymph node metastasis, BMP2, BMP7, integrin alpha 5, integrin beta 1, ZEB2, EPITHELIAL-MESENCHYMAL TRANSITION, CANCER CELLS, GENE-EXPRESSION, BREAST-CANCER, TGF-BETA, BONE, INHIBITION, PROTEINS, SURVIVAL
  • Hacettepe University Affiliated: Yes

Abstract

Ovarian cancer (OC) is clinically important because it is diagnosed late and has metastasis when it is diagnosed. Mortality risk increases 2.75 times in the presence of lymph node (LN) metastasis. During metastasis, many molecules including BMPs originated from stroma, and tumor cells participate through transcription factors and integrins for cytoskeleton regulation during cell migration. We hypothesized an inverse correlation between BMP2 and BMP7 along with changes in ZEB2, and integrin alpha 5 beta 1 in high-grade OCs in relation to LN metastasis. The BMP2 immunoreactivity was strong along with strong ZEB2 and weak integrins' immunoreactivity in samples with LN metastasis. Strong immunoreactivity of BMP7 was accompanied by strong immunoreactivity of integrins in the samples without LN metastasis. Study results showed BMP2's strong positive immunoreactivity and weak BMP7 immunoreactivity in tumor cells with a significantly weak inverse correlation. This inverse correlation should be considered as both BMPs have different effects in the window of cancer progression and invasion.