Studies on the synthesis of the azocino[4,3-b]indole framework and related compounds

Uludag N., Patir S.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.44, no.6, pp.1317-1322, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1002/jhet.5570440613
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1317-1322
  • Hacettepe University Affiliated: Yes

Abstract

An efficient method for the synthesis of C-4 position alkylated azocino[4,3-b]indole 13 and 18 is described. Reduction of compounds 5, 6, 7 and 8 yielded the corresponding alcohols. Compounds 5, 6, 7 and 8 were synthesized through several steps starting from 1. The resulting alcohols underwent acid catalyzed ring closure to give tetracyclic azocino[4,3-b]indole 9, 10, 11 and 12. Finally, compounds 9 and 17 were alkylated at C-4 position to the corresponding products 13 and 18. The structure of the compounds 13 and 18 has been confirmed by X-ray single crystal analysis.