Wwox and Ap2 gamma expression levels predict tamoxifen response

Guler G., Iliopoulos D., Guler N., Himmetoglu C., Hayran M., Huebner K.

CLINICAL CANCER RESEARCH, cilt.13, sa.20, ss.6115-6121, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 20
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1158/1078-0432.ccr-07-1282
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6115-6121
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl alpha, in breast cancers, to determine their roles in tamoxifen resistance. The hypothesis was that sequestration of Wwox interactors in the cytoplasm might control tamoxifen response.