Wwox and Ap2 gamma expression levels predict tamoxifen response

Guler G., Iliopoulos D., Guler N., Himmetoglu C., Hayran M., Huebner K.

CLINICAL CANCER RESEARCH, vol.13, no.20, pp.6115-6121, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 20
  • Publication Date: 2007
  • Doi Number: 10.1158/1078-0432.ccr-07-1282
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6115-6121
  • Hacettepe University Affiliated: Yes


Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl alpha, in breast cancers, to determine their roles in tamoxifen resistance. The hypothesis was that sequestration of Wwox interactors in the cytoplasm might control tamoxifen response.