The Effects of a High-Fat, Low-Carbohydrate Diet on the Prognosis of Patients with an Acute Attack of Chronic Obstructive Pulmonary Disease

Tumer G., Mercanligil S. M., UZUN O., Aygun C.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.29, no.4, pp.895-904, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2009
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.895-904
  • Hacettepe University Affiliated: Yes


Objective: Acute exacerbations are the most frequent cause of medical visits, hospitalizations, admissions and death among patients with chronic obstructive pulmonary disease (COPD). Our objective was to investigate the effects of a high-fat low-carbohydrate (CHO) diet on the prognosis of patients hospitalized for an acute exacerbation of COPD. Material and Methods: Thirty male patients with COPD, hospitalized for acute exacerbation were randomized into two groups. Standard hospital diet was administered to group I for 10 days and an experimental diet comprising of 50% standard hospital diet and 50% of a special enteral product containing high-fat low-CHO was administered to group II Pulmonary function tests, anthropometric measurements and blood gas analysis were per-formed on the first and tenth days of the study. All patients completed a questionnaire regarding socio-economic status and nutritional habits. Results: Pulmonary function tests revealed statistically significant differences in tidal volume (TV) and forced vital capacity (FVC) between the measurements of day I and day 10 of the two groups with better results in group 11 (p< 0.05). There was no significant difference between groups on blood gas analysis parameters on days 1, 3,5,7, and 9 (p> 0.05), yet there was an improvement (increase in PaO2, decrease in PaCO2). Conclusion: A high-fat low-CHO diet can improve the prognosis of COPD patients with acute exacerbation. Since nutritional interventions can improve treatment outcomes and quality of life in COPD patients, multi-center studies with a larger sample size and long-term nutrition support are needed.