Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells

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Alarcon M., Zeybek N. D., Müftüoğlu S. F.

BALKAN MEDICAL JOURNAL, cilt.35, sa.3, ss.256-262, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/balkanmedj.2017.0604
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.256-262
  • Anahtar Kelimeler: Apoptosis, atorvastatin, autophagy, breast cancer, cytotoxicity, MCF-7 cells, IN-VITRO, STATIN USE, INHIBITION, DEATH, LOVASTATIN, APOPTOSIS, REDUCTASE, INVASION, AGENTS, RISK
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Recently, cytotoxic effects of statins on breast cancer cells have been reported. However, the mechanism of anti-proliferative effects is currently unknown. Autophagy is non-apoptotic programmed cell death, which is characterized by degradation of cytoplasmic components and as having a role in cancer pathogenesis.