Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells
BALKAN MEDICAL JOURNAL, cilt.35, sa.3, ss.256-262, 2018 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.4274/balkanmedj.2017.0604
- Dergi Adı: BALKAN MEDICAL JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.256-262
- Anahtar Kelimeler: Apoptosis, atorvastatin, autophagy, breast cancer, cytotoxicity, MCF-7 cells, IN-VITRO, STATIN USE, INHIBITION, DEATH, LOVASTATIN, APOPTOSIS, REDUCTASE, INVASION, AGENTS, RISK
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Recently, cytotoxic effects of statins on breast cancer cells have been reported. However, the mechanism of anti-proliferative effects is currently unknown. Autophagy is non-apoptotic programmed cell death, which is characterized by degradation of cytoplasmic components and as having a role in cancer pathogenesis.