Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells

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Alarcon M., Zeybek N. D., Müftüoğlu S. F.

BALKAN MEDICAL JOURNAL, vol.35, no.3, pp.256-262, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.4274/balkanmedj.2017.0604
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.256-262
  • Keywords: Apoptosis, atorvastatin, autophagy, breast cancer, cytotoxicity, MCF-7 cells, IN-VITRO, STATIN USE, INHIBITION, DEATH, LOVASTATIN, APOPTOSIS, REDUCTASE, INVASION, AGENTS, RISK
  • Hacettepe University Affiliated: Yes

Abstract

Background: Recently, cytotoxic effects of statins on breast cancer cells have been reported. However, the mechanism of anti-proliferative effects is currently unknown. Autophagy is non-apoptotic programmed cell death, which is characterized by degradation of cytoplasmic components and as having a role in cancer pathogenesis.