Copy For Citation
Alarcon M., Zeybek N. D., Müftüoğlu S. F.
BALKAN MEDICAL JOURNAL, vol.35, no.3, pp.256-262, 2018 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
35
Issue:
3
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Publication Date:
2018
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Doi Number:
10.4274/balkanmedj.2017.0604
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Journal Name:
BALKAN MEDICAL JOURNAL
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Page Numbers:
pp.256-262
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Keywords:
Apoptosis, atorvastatin, autophagy, breast cancer, cytotoxicity, MCF-7 cells, IN-VITRO, STATIN USE, INHIBITION, DEATH, LOVASTATIN, APOPTOSIS, REDUCTASE, INVASION, AGENTS, RISK
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Hacettepe University Affiliated:
Yes
Abstract
Background: Recently, cytotoxic effects of statins on breast cancer cells have been reported. However, the mechanism of anti-proliferative effects is currently unknown. Autophagy is non-apoptotic programmed cell death, which is characterized by degradation of cytoplasmic components and as having a role in cancer pathogenesis.