Effects of blood transfusion on cytokine profile and pulmonary function in patients with thalassemia major

Gülhan B., Yalçın E., Ünal Ş., Oğuz B., Özçelik U., Ersöz D., ...Daha Fazla

CLINICAL RESPIRATORY JOURNAL, cilt.10, sa.2, ss.153-162, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/crj.12193
  • Dergi Adı: CLINICAL RESPIRATORY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.153-162
  • Anahtar Kelimeler: cytokine, ferritin, pulmonary function tests, thalassemia major, BETA-THALASSEMIA, FUNCTION ABNORMALITIES, DIFFUSING-CAPACITY, LUNG CAPACITY, IRON OVERLOAD, DISEASE, INTERLEUKIN-8, DYSFUNCTION, CHILDREN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background and AimsThalassemia major (TM) is characterized by abnormal hemoglobin synthesis, which results in decreased oxygen delivery to the tissues, ineffective erythropoiesis and iron overload. The purpose of this study was to find out the predominant type of lung mechanical abnormalities in TM patients, the prevalence of the change in pulmonary diffusing capacity and to search the association of cytokines with pulmonary function tests (PFTs).