Effects of blood transfusion on cytokine profile and pulmonary function in patients with thalassemia major

Gülhan B., Yalçın E., Ünal Ş., Oğuz B., Özçelik U., Ersöz D., ...More

CLINICAL RESPIRATORY JOURNAL, vol.10, no.2, pp.153-162, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1111/crj.12193
  • Journal Name: CLINICAL RESPIRATORY JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.153-162
  • Keywords: cytokine, ferritin, pulmonary function tests, thalassemia major, BETA-THALASSEMIA, FUNCTION ABNORMALITIES, DIFFUSING-CAPACITY, LUNG CAPACITY, IRON OVERLOAD, DISEASE, INTERLEUKIN-8, DYSFUNCTION, CHILDREN
  • Hacettepe University Affiliated: Yes

Abstract

Background and AimsThalassemia major (TM) is characterized by abnormal hemoglobin synthesis, which results in decreased oxygen delivery to the tissues, ineffective erythropoiesis and iron overload. The purpose of this study was to find out the predominant type of lung mechanical abnormalities in TM patients, the prevalence of the change in pulmonary diffusing capacity and to search the association of cytokines with pulmonary function tests (PFTs).