Immunohistochemical study of cyclosporin-induced gingival overgrowth in renal transplant recipients


BULUT O., SOKMENSUER L., BULUT S., TASMAN F., Muftuoglu S. F.

JOURNAL OF PERIODONTOLOGY, vol.75, no.12, pp.1655-1662, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 12
  • Publication Date: 2004
  • Doi Number: 10.1902/jop.2004.75.12.1655
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1655-1662
  • Hacettepe University Affiliated: Yes

Abstract

Background: Cyclosporin A (CsA) is an immunosuppressant widely used to treat transplant patients and various systemic diseases with immunological components. Gingival overgrowth (GO) is a common side effect of CsA administration; however, the pathogenesis of drug-induced GO is poorly understood. The aim of this study was to evaluate the expression of Ki-67, activation molecules (CD71, CD98), leukocytes activation antigens (CD45, CD45RA, CD50, CD11a, CD162, CD227, CD231), neurothelin (CD147), and novel endothelial cell antigens (B-F45, SCF87, B-D46, B-C44, VJ1/6) in gingival tissue in renal transplant recipients treated with CsA.