The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome

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Diker S., Has A. C., Kurne A., GÖÇMEN R., Oguz K. K., KARABUDAK R.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.10, pp.14-21, 2016 (SCI-Expanded) identifier identifier identifier


Background: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline.