The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome


Diker S., Has A. C. , Kurne A., GÖÇMEN R., Oguz K. K. , KARABUDAK R.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.10, pp.14-21, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2016
  • Doi Number: 10.1016/j.msard.2016.08.008
  • Journal Name: MULTIPLE SCLEROSIS AND RELATED DISORDERS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.14-21

Abstract

Background: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline.