The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome

Diker, Sevda; Has, Arzu; Kurne, Asli; GÖÇMEN, RAHŞAN; Oguz, Kader; KARABUDAK, RANA

doi:10.1016/j.msard.2016.08.008

The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome

Diker S., Has A. C., Kurne A., GÖÇMEN R., Oguz K. K., KARABUDAK R.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, cilt.10, ss.14-21, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.msard.2016.08.008
Dergi Adı: MULTIPLE SCLEROSIS AND RELATED DISORDERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.14-21
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline.