The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome


Diker S., Has A. C. , Kurne A., GÖÇMEN R. , Oguz K. K. , KARABUDAK R.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, cilt.10, ss.14-21, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.msard.2016.08.008
  • Dergi Adı: MULTIPLE SCLEROSIS AND RELATED DISORDERS
  • Sayfa Sayıları: ss.14-21

Özet

Background: Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives: To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline.