Effect of High-dose Ascorbic Acid on Prostate Cancer Cells and Angiogenesis

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MANGIR N., MacNeil S.

The Bulletin of Urooncology, cilt.19, 2020 (Hakemli Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/uob.galenos.2020.1761
  • Dergi Adı: The Bulletin of Urooncology
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Angiogenesis, ascorbic acid, prostate cancer, CLINICAL-TRIAL, VITAMIN-C
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Objective: Ascorbic acid (AA), at physiological concentrations, is a well known anti-oxidant but, at higher concentrations, it can be selectively toxic to cancer cells. Controversial data have shown that administration of intravenous high-dose AA can improve therapeutic outcomes in cancer patients. These effects are thought to occur mainly due to direct cytotoxicity mediated by generation of reactive oxygen species. The anti-tumour effects of AA can also be due to inhibition of angiogenesis, however, this has been poorly studied. This study aimed to investigate the effect of AA on prostate cancer cells and angiogenesis.