The molecule of the title compound, [Ni2Zn(C17H20N2O2)(2)(C2H3O2)(2)(C3H7NO)(2)], contains a linear hetero-trinuclear arrangement with a central Zn-II ion located on an inversion centre. The Zn center dot center dot center dot Ni pairs are triply bridged via O atoms of SALPD(2-) [N,N'-bis(salicylidene)-1,3-propanediaminate] and acetate ligands. The central Zn II ion is in a distorted octahedral coordination environment formed by four O atoms of two SALPD(2-) ligands in the equatorial plane and two O atoms of two symmetry- related acetate ligands in the axial positions. The terminal Ni II ions, related by an inversion centre, also have distorted octahedral coordination environments formed by two O and two N atoms of SALPD(2-) ligands in the equatorial plane; the axial positions are occupied by O atoms of dimethylformamide and acetate ligands, which are trans with respect to the terminal Ni atoms. The crystal structure is stabilized by weak intermolecular C-H center dot center dot center dot O hydrogen bonds.