Reduced Tc-99m DMSA uptake in a patient with renal tubular acidosis: Effect of acid-base imbalance

Caglar M. , Topaloglu R.

ANNALS OF NUCLEAR MEDICINE, cilt.16, sa.7, ss.499-501, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Konu: 7
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/bf02988651
  • Sayfa Sayıları: ss.499-501


Tc-99m dimercaptosuccinic acid (DMSA) is used as a renal cortical imaging agent to detect parenchymal abnormalities especially in children. Kidney uptake of DMSA provides an index for evaluation of a functional tubular mass, which depends on the renal blood flow and proximal tubular cell membrane transport function. We here report a boy with renal tubular acidosis, which has noticeably reduced uptake on his Tc-99m DMSA scintigraphy, despite a totally normal Tc-99m MAG-3 study. The case reported here clearly demonstrates a situation in which renal uptake of DMSA may be dissociated from a functional renal mass and the importance of acid-base balance which alters Tc-99m DMSA uptake.