Endocannabinoid System in the Airways


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BOZKURT T. E.

MOLECULES, vol.24, no.24, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 24
  • Publication Date: 2019
  • Doi Number: 10.3390/molecules24244626
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: cannabinoids, endocannabinoids, airway, cannabinoid receptor, fatty acid amide hydrolase, monoacylglycerol lipase, CANNABINOID RECEPTOR 1, INDUCED PULMONARY INFLAMMATION, ACID AMIDE HYDROLASE, GUINEA-PIG, CB2 RECEPTORS, MURINE MODEL, MOLECULAR CHARACTERIZATION, MONOACYLGLYCEROL LIPASE, SMOKED MARIJUANA, SMOOTH-MUSCLE
  • Hacettepe University Affiliated: Yes

Abstract

Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread biological effects. The significant immune-modulatory role of cannabinoids has suggested their therapeutic use in several inflammatory conditions. Airways are prone to environmental irritants and stimulants, and increased inflammation is an important process in most of the respiratory diseases. Therefore, the main strategies for treating airway diseases are suppression of inflammation and producing bronchodilation. The ability of cannabinoids to induce bronchodilation and modify inflammation indicates their importance for airway physiology and pathologies. In this review, the contribution of cannabinoids and the endocannabinoid system in the airways are discussed, and the existing data for their therapeutic use in airway diseases are presented.