Nicolau Syndrome Secondary to Subcutaneous Glatiramer Acetate Injection

Demircan C., AKDOĞAN N., Elmas L.

International Journal of Lower Extremity Wounds, cilt.22, sa.1, ss.149-151, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1177/1534734620973144
  • Dergi Adı: International Journal of Lower Extremity Wounds
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.149-151
  • Anahtar Kelimeler: Nicolau syndrome, glatiramer acetate, subcutaneous injection, ulcerative lesion
  • Hacettepe Üniversitesi Adresli: Evet

Özet

© The Author(s) 2020.Nicolau syndrome, also known as embolia cutis medicamentosa, is a rare complication of injectable drugs. Patients present with pain at injection site, followed by swelling, erythema, purple, hemorrhagic patches and lastly ulcer formation. A variety of intramuscular agents have been implicated as responsible. We report a case of a 26-year-old woman with a history of a purple lesion on her thigh who was diagnosed with Nicolau syndrome due to subcutaneous administration of glatiramer acetate. The patient was followed up with topical mupirocin. On follow-up, although the patient stated that she continued using glatiramer acetate, no new lesions appeared and the existing lesion continued to shrink. Nicolau syndrome seems to have an unpredictable and unavoidable course. This case suggests that physicians should have a high index of suspicion for the presence of Nicolau syndrome in patients presenting with necrotic or ulcerative lesions with a history of using injectable drugs.