Lipid Droplets in Health and Disease

Onal G., Kutlu O., Gozuacik D., EMRE S.

LIPIDS IN HEALTH AND DISEASE, cilt.16, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 16
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s12944-017-0521-7
  • Dergi Adı: LIPIDS IN HEALTH AND DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Lipid droplets, lipolysis, lipophagy, chaperone-mediated autophagy, HEPATITIS-C-VIRUS, CHAPERONE-MEDIATED AUTOPHAGY, HORMONE-SENSITIVE LIPASE, ADIPOSE TRIGLYCERIDE LIPASE, CHANARIN-DORFMAN-SYNDROME, FAT-SPECIFIC PROTEIN-27, STORAGE DISEASE, CHOLESTEROL EFFLUX, CORE PROTEIN, OIL BODIES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydrophobic neutral lipid core surrounding by a phospholipid monolayer membrane with various decorating proteins. Degradation of LDs provide metabolic energy for divergent cellular processes such as membrane synthesis and molecular signaling. Lipolysis and autophagy are two main catabolic pathways of LDs, which regulate lipid metabolism and, thereby, closely engaged in many pathological conditons. In this review, we first provide an overview of the current knowledge on the structural properties and the biogenesis of LDs. We further focus on the recent findings of their catabolic mechanism by lipolysis and autophagy as well as their connection ragarding the regulation and function. Moreover, we discuss the relevance of LDs and their catabolism-dependent pathophysiological conditions.