Molecular mechanisms of signal transduction: Epidermal growth factor receptor family, Vascular endothelial growth factor family, Kit, Platelet-derived growth factor receptor, Ras

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Erman M.

JOURNAL OF BUON, vol.12, 2007 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 12
• Publication Date: 2007
• Journal Name: JOURNAL OF BUON
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Hacettepe University Affiliated: Yes

Abstract

One of the major mechanisms of communication between cells is the binding of polypeptide ligands to cell surface receptors possessing tyrosine kinase (TK) activity. Though many actions of these receptors involve physiological processes, Perturbation of TK signaling can result in malignant transformation.