Research Information System
22nd World Cogress of Psychophysiology, Krakow, Poland, 8 - 11 July 2025, vol.213, pp.11, (Summary Text)
https://www.sciencedirect.com/science/article/pii/S0167876025001394
https://www.sciencedirect.com/science/article/pii/S0167876025006944?via%3Dihub
The findings in the literature regarding the electrophysiological microstates of the brain in neurodegenerative diseases are inconsistent. Microstate analysis is a method used to examine the short-term dynamic organization of the brain. This study investigated whether the microstates of resting-state EEG activity differed among frontotemporal dementia (FTD), Alzheimer's dementia (AD), and healthy control (HC) groups. Eighty-six participants aged between 44 and 79 were included in the study (36 AD, 27 HC, 23 FTD). The groups were matched for age and gender (p N 0.05). EEG data were cleaned of motion artifacts using independent component analysis, preprocessed with band-pass (1-40 Hz) and notch filtering, and then down-sampled (125 Hz). Microstate analysis was conducted in two stages: at the individual and group levels. We identified four microstates (A, B, C, and E) that consistently explainedthedataacrosstheAD,FTD,andHCgroupsusingmicrostate analysis. Regarding microstate temporal dynamics, we found increased microstate A (Time Coverage- Occurrence) and E (Mean Duration- Time Coverage- Occurrence) and decreased microstate C (Mean Duration Time Coverage- Occurrence) in FTD and AD compared to HC. Combined EEG-fMRI studies have shown that dynamic temporal microstates are associated with specific large-scale networks. For example, microstate C has been associated with the posterior default mode network (pDMN), while microstate E topologies are linked to the anterior default mode network (aDMN). These findings support previous EEG-fMRI studies suggesting that neurodegenerative processes in FTD and AD are associated with decreased pDMN connectivity and increased aDMN connectivity. Notably, there was no significant difference in microstate dynamics between the FTD and AD groups. This indicates that the effects of both pathologies on the dynamic brain organization of microstates are similar in certain aspects