From Shadows to Diagnosis: Unraveling L-2 Hydroxyglutaric Aciduria in Adulthood
ARCHIVES OF EPILEPSY, vol.30, no.2, pp.53-55, 2024 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 30 Issue: 2
- Publication Date: 2024
- Doi Number: 10.4274/archepilepsy.2024.24114
- Journal Name: ARCHIVES OF EPILEPSY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.53-55
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
L-2-hydroxyglutaric aciduria (L2HGA) is a rare autosomal recessive metabolic disorder that causes central nervous system dysfunction. We present the case of a 33-year-old woman with macrocephaly, developmental delay, cerebellar ataxia, pyramidal signs, and seizures. Despite typical clinical features and suggestive magnetic resonance imaging findings, the diagnosis was not made. Genetic analysis revealed a homozygous missense mutation in the L-2-hydroxyglutarate dehydrogenase (L2HGDH) gene. Treatment with riboflavin and L-carnitine was initiated. L2HGA should be considered in the differential diagnosis, even in adults, when suggestive imaging findings are present. Early diagnosis is crucial for better outcomes.