An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy

Yonar D., Suloglu A., SELMANOĞLU G., Sunnetcioglu M. M.

BMC MOLECULAR AND CELL BIOLOGY, vol.20, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2019
  • Doi Number: 10.1186/s12860-019-0205-4
  • Journal Name: BMC MOLECULAR AND CELL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Photodynamic therapy, Hypericin, Membrane fluidity, EPR spin labeling, CANCER, MEMBRANE, FLUIDITY
  • Hacettepe University Affiliated: Yes

Abstract

Background: Colon cancer affects 1.23 million people worldwide and is the third most common malignant disease in men and the second in women. The only curative treatment is surgical resection, but a significant number of patients develop local recurrence or distant metastases. One of the alternative treatment methods for colon cancer is photodynamic therapy (PDT). In recent years, hyperidn (HYP) derived from Hypericum perforatum has been suggested as a strong candidate photosensitizer for PDT. Our interest is focused on the biophysical changes in colon cancer cells in relation to HYP-mediated PDT.