Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek, MEHMET; BAL, I.; Sara, Yildirim; ONUR, Rustu; Severcan, Feride

doi:10.1016/j.bbagen.2013.09.010

Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek N. S., BAL I. B., Sara Y., ONUR R., Severcan F.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1840, no.1, pp.406-415, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 1840 Issue: 1
Publication Date: 2014
Doi Number: 10.1016/j.bbagen.2013.09.010
Journal Name: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.406-415
Hacettepe University Affiliated: Yes

Abstract

Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.