Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek, MEHMET; BAL, I.; Sara, Yildirim; ONUR, Rustu; Severcan, Feride

doi:10.1016/j.bbagen.2013.09.010

Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Atıf İçin Kopyala

Ozek N. S., BAL I. B., Sara Y., ONUR R., Severcan F.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1840, sa.1, ss.406-415, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 1840 Sayı: 1
Basım Tarihi: 2014
Doi Numarası: 10.1016/j.bbagen.2013.09.010
Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.406-415
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.