Thiol/disulfide homeostasis in asphalt workers

YILMAZ, ÖMER; Bal, Ceylan; Neselioglu, Salim; Buyuksekerci, Murat; Gunduzoz, Meside; Eren, Funda; Tutkun, Lutfiye; YILMAZ, FATMA

doi:10.1080/19338244.2015.1076760

Thiol/disulfide homeostasis in asphalt workers

Atıf İçin Kopyala

YILMAZ Ö. H., Bal C., Neselioglu S., Buyuksekerci M., Gunduzoz M., Eren F., ...Daha Fazla

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, cilt.71, sa.5, ss.268-272, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 71 Sayı: 5
Basım Tarihi: 2016
Doi Numarası: 10.1080/19338244.2015.1076760
Dergi Adı: ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.268-272
Hacettepe Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate thiol/disulfide homeostasis in asphalt workers who are exposed to polycyclic aromatic hydrocarbons occupationally. The study was carried out in 34 nonsmoker asphalt workers. Additionally, 35 healthy nonsmoker volunteers were recruited as control group. Thiol and disulfide concentrations were determined using the novel automated measurement method. Levels of urinary 1-OH-pyrene were analyzed by liquid chromatography. Disulfide/thiol ratio was significantly higher in exposed group (p = .034). Also, a positive correlation was detected between disulfide/thiol ratio and 1-OH-pyrene values (r = .249, p = .036). Thiol/disulfide homeostasis was found to be disturbed in asphalt workers. The novel test used in this study may be useful for evaluating the oxidative status in polycyclic aromatic hydrocarbon (PAH) exposure.