Induction of cytokines by a phenylpropanoid glycoside acteoside

INOUE M., UEDA M., OGIHARA Y., Saracoglu I.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, cilt.21, sa.12, ss.1394-1395, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Konu: 12
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1248/bpb.21.1394
  • Sayfa Sayıları: ss.1394-1395


A phenylpropanoid glycoside acteoside was found to induce interleukin (IL)-1, IL-6, and tumor necrosis factor-a (TNF-alpha) in macrophage-like cell line J774.A1 at 1-100 ng/ml, In addition,, when the stimulatory action of acteoside was studied using the bovine glomerular endothelial cell line GEN-T, it stimualted IL-6 production. These stimulatory activities were not abolished by treatment with polymixin B, which inactivates lipopolysaccharide (LPS), indicating that the action was not a contamination of LPS.