Induction of cytokines by a phenylpropanoid glycoside acteoside

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INOUE M., UEDA M., OGIHARA Y., Saracoglu I.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol.21, no.12, pp.1394-1395, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 12
  • Publication Date: 1998
  • Doi Number: 10.1248/bpb.21.1394
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1394-1395
  • Hacettepe University Affiliated: Yes


A phenylpropanoid glycoside acteoside was found to induce interleukin (IL)-1, IL-6, and tumor necrosis factor-a (TNF-alpha) in macrophage-like cell line J774.A1 at 1-100 ng/ml, In addition,, when the stimulatory action of acteoside was studied using the bovine glomerular endothelial cell line GEN-T, it stimualted IL-6 production. These stimulatory activities were not abolished by treatment with polymixin B, which inactivates lipopolysaccharide (LPS), indicating that the action was not a contamination of LPS.