Formulation and Evaluation of Organogels Containing Hyaluronan Microparticles for Topical Delivery of Caffeine


Simsolo E. E. , EROĞLU İ. , TUNCAY TANRIVERDİ S., Ozer O.

AAPS PHARMSCITECH, cilt.19, sa.3, ss.1367-1376, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1208/s12249-018-0955-x
  • Dergi Adı: AAPS PHARMSCITECH
  • Sayfa Sayıları: ss.1367-1376

Özet

Cellulite is a dermal disorder including the extracellular matrix, the lymphatic and microcirculatory systems and the adipose tissue. Caffeine is used as the active moiety depending its preventive effect on localization of fat in the cellular structure. Hyaluronic acid (hyaluronan-HA) is a natural constituent of skin that generates formation and poliferation of new cells having a remarkable moisturizing ability. The aim of this study is to formulate HA microparticles loaded with caffeine via spray-drying method. Resulting microparticle formulations (33.97 +/- 0.3 mu m, span < 2, 88.56 +/- 0.42% encapsulation efficiency) were distributed in lecithin organogels to maintain the proper viscosity for topical application. Following the characterization and cell culture studies, in vitro drug release and ex vivo permeation studies were performed. The accumulated amount of caffeine was twice higher than the aqueous solution for the microparticle-loaded organogels at 24 h (8262,673 mu g/cm(2) versus 4676,691 mu g/cm(2)). It was related to the sustained behaviour of caffeine release from the microparticles. As a result, lecithin organogel containing HA-encapsulated microparticles could be considered as suitable candidate formulations for efficient topical drug delivery system of caffeine. In addition to that, synergistic effect of this combination appears as a promising approach for long-acting treatment of cellulite.