Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

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MacLennan C., Fieschi C., Lammas D., Picard C., Dorman S., Sanal O., ...More

JOURNAL OF INFECTIOUS DISEASES, vol.190, no.10, pp.1755-1757, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 190 Issue: 10
  • Publication Date: 2004
  • Doi Number: 10.1086/425021
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1755-1757
  • Hacettepe University Affiliated: No


Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)-gamma axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN-gamma-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-gamma-independent pathways. Investigation of the IL-12/IL-23-IFN-gamma axis should be considered in patients with invasive salmonella disease.