Polyneuropathy as paraneoplastic syndrome in a patient with metastatic diffuse large B-cell lymphoma


BOSTAN E., Jarbou A., AKDOĞAN N., ÜNER A., KAVUNCUOĞLU A.

TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY, vol.15, no.3, pp.77-79, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.4103/tjd.tjd_38_21
  • Journal Name: TURK DERMATOLOJI DERGISI-TURKISH JOURNAL OF DERMATOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE
  • Page Numbers: pp.77-79
  • Keywords: B-cell lymphoma, paraneoplastic, polyneuropathy
  • Hacettepe University Affiliated: Yes

Abstract

Paraneoplastic syndromes are multisystemic diseases that are seen in association with solid organ tumors and lymphomas. Immune-mediated polyneuropathy, encephalopathy, cerebellar degeneration, and Guillain-Barre syndrome have all been described as paraneoplastic neurologic disorders. Clinical symptoms may appear before the diagnosis of associated malignancy creating diagnostic confusion. Tumor-derived peptides, hormones, and mediators are shown to be associated with paraneoplastic syndromes. Herein, we present an unusual case of stage 4 diffuse large B-cell lymphoma with cutaneous metastatic nodules presenting initially as paraneoplastic polyneuropathy.