Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study
JOURNAL OF PEDIATRIC SURGERY, vol.41, no.6, pp.1134-1138, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 41 Issue: 6
- Publication Date: 2006
- Doi Number: 10.1016/j.jpedsurg.2006.02.003
- Journal Name: JOURNAL OF PEDIATRIC SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1134-1138
- Hacettepe University Affiliated: Yes
Abstract
Background/Purpose: The presence of granulocyte colony-stimulating factor (G-CSF) in human milk and the expression of G-CSF receptors on intestinal villous enterocytes of neonates suggest that G-CSF has a role in the development and integrity of the gastrointestinal tract. We hypothesized that enteral recombinant human G-CSF (rhG-CSF) given to preterm infants with necrotizing enterocolitis (NEC) in the earlier stages could protect against disease progression and complications.