Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells - An immuno electron microscopic study

Seftalioglu A., Karakus S., Dundar S., Can B., Erdemli E., Irmak M., ...Daha Fazla

ACTA ONCOLOGICA, cilt.42, sa.1, ss.71-74, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Konu: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1080/0891060310002267
  • Sayfa Sayıları: ss.71-74


Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.