Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells - An immuno electron microscopic study
ACTA ONCOLOGICA, vol.42, no.1, pp.71-74, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 42 Issue: 1
- Publication Date: 2003
- Doi Number: 10.1080/0891060310002267
- Journal Name: ACTA ONCOLOGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.71-74
- Hacettepe University Affiliated: No
Abstract
Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.