In vitro efficacy of antibiotics against three respiratory tract pathogens in a Turkish University hospital

Gur D., ŞENER B., Tunckanat F., Kocagoz S., ÜNAL S.

Mediterranean Journal of Infectious and Parasitic Diseases, vol.12, no.3, pp.69-72, 1997 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 1997
  • Journal Name: Mediterranean Journal of Infectious and Parasitic Diseases
  • Journal Indexes: Scopus
  • Page Numbers: pp.69-72
  • Keywords: Haemophilus, Moraxella, Respiratory pathogens, S. pneumoniae
  • Hacettepe University Affiliated: Yes


In vitro activities of penicillin (ampicillin), amoxycillin clavulanate, cefuroxime, cefaclor, cefotaxime, sparfloxacin, dirithromycin, erythromycin, chloramphenicol and cotrimoxazole were investigated in respiratory tract isolates of S. pneumoniae (no. 50), H. influenzae (no. 31) and M. catarrhalis (no. 26) in a Turkish hospital using the E-test. Resistance to penicillin was 24% in S. pneumoniae. Twenty-three percent of H. influenzae and 96% of M. catarrhalis were resistant to ampicillin by production of β-lactamases. Resistance to cotrimoxazole was 39% in Haemophilus, 8% in Moraxella and 22% in S. pneumoniae. Six percent of S. pneumoniae and 4% of Moraxella were resistant to erythromycin. Among the oral agents, amoxycillin/clavulanate, cefuroxime and cefaclor were the most active agents in vitro. Resistance to commonly used antibiotics in these respiratory tract pathogens necessitates the use of antibiotic susceptibility tests even when empirical therapy is initiated.