A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration.

Bal, Zeynep; Korkusuz, Feza; Ishiguro, Hiroyuki; Okada, Rintaro; Kushioka, Junichi; Chijimatsu, Ryota; Kodama, Joe; Tateiwa, Daisuke; Ukon, Yuichiro; Nakagawa, Shinichi; Dede, Eda; Gizer, Merve; Korkusuz, PETEK; Yoshikawa, Hideki; Kaito, Takashi

doi:10.1016/j.spinee.2021.01.019

A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration.

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Bal Z., Korkusuz F., Ishiguro H., Okada R., Kushioka J., Chijimatsu R., ...More

The spine journal : official journal of the North American Spine Society, vol.21, pp.865-873, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21
Publication Date: 2021
Doi Number: 10.1016/j.spinee.2021.01.019
Journal Name: The spine journal : official journal of the North American Spine Society
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
Page Numbers: pp.865-873
Keywords: Bone regeneration, Bone morphogenetic protein, Nano-hydroxyapatite, Synthetic polymer, Spinal fusion, Biomaterials, BMP CARRIERS, DELIVERY
Hacettepe University Affiliated: Yes

Abstract

BACKGROUND: Efficient bone regeneration using recombinant human bone morphogenetic protein-2 (BMP-2) is needed to reduce side effects caused by high-dose BMP-2 use. The composite material of polylactic acid-polyethene glycol (PLA-PEG) for sustained release and an osteogenic nano-hydroxyapatite (nHAp) can contribute to efficient bone regeneration by BMP-2.