This study explored the association of quality of life (QOL) during the pandemic with family climate and family integrity. Participants were 1085 parents from Turkey. According to the findings, the participants' QOL, which demonstrated their judgments regarding their physical health, mental well-being, social relations, and general happiness, was greatly influenced by the COVID-19 pandemic. Women were seen to have lower perceptions in relatedness in the family and cognitive cohesion than male participants. While there was a positive, but low, association between the variables, there were positive and high correlations between cognitive cohesion and relatedness in the family. When the mediation analyses were evaluated, it was concluded that QOL predicted the sense of family coherence alone, while intergenerational authority influenced other variables. The results highlighted the importance of family climate-based prevention and intervention targeting the promotion of family coherence.