Longitudinal Evaluation of Sternocleidomastoid Muscle Stiffness and Self-Reported Fibrosis-Related Symptoms After Radiotherapy in Patients with Head and Neck Cancer
Cancers, vol.18, no.12, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 12
- Publication Date: 2026
- Doi Number: 10.3390/cancers18121928
- Journal Name: Cancers
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, CINAHL, EMBASE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Keywords: head and neck cancer, muscle stiffness, patient-reported outcomes, radiation fibrosis, radiotherapy, shear wave elastography, sternocleidomastoid muscle
- Hacettepe University Affiliated: Yes
Abstract
Background/Objectives: Post-radiation fibrosis is a common complication in patients with head and neck cancer (HNC), characterised by increased tissue stiffness and functional limitations. Shear wave elastography (SWE) enables objective assessment of tissue stiffness, while self-reported outcome measures provide insight into symptom burden. However, the longitudinal evolution of these outcomes and their relationship remains insufficiently described. This study aimed to characterise post-radiation fibrosis over time using objective SWE measurements of sternocleidomastoid (SCM) muscle stiffness and self-reported fibrosis-related symptoms, and to examine their longitudinal association. Methods: This prospective longitudinal study included 56 patients with HNC undergoing primary or postoperative (chemo)radiotherapy. Muscle stiffness was measured using SWE, and fibrosis-related symptoms were assessed with the Lymphoedema Symptom Intensity and Distress Survey-Head and Neck (LSIDS-H&N) at 1 week, 6 weeks, 12 weeks, 6 months, and 12 months after the start of radiotherapy. Longitudinal analyses were performed using mixed-effects models adjusted for surgery and radiation dose, and within-subject associations were evaluated using repeated measures correlation. Results: Muscle stiffness increased over time, with estimated mean stiffness values rising from 4.12 m/s at baseline to 4.76 m/s at 6 months and 4.92 m/s at 12 months. Significant increases were observed at 6 months (p = 0.007) and 12 months (p = 0.012) compared with baseline. In contrast, self-reported fibrosis-related symptoms remained stable, with no significant differences between time points. No significant within-subject association was found between muscle stiffness and self-reported fibrosis-related symptoms (r = −0.13, p = 0.498). Conclusions: Muscle stiffness measured with SWE increased over time following radiotherapy, whereas self-reported fibrosis-related symptoms remained stable. No significant longitudinal association was found between these outcomes, suggesting they may capture different aspects of fibrosis.