Effects of flavonoid quercetin on survival of motor neuron gene expression


Uzunalli G., Bora-Tatar G., Dayangac-Erden D. , Erdem-Yurter H.

CELL BIOLOGY INTERNATIONAL, cilt.39, ss.350-354, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/cbin.10395
  • Dergi Adı: CELL BIOLOGY INTERNATIONAL
  • Sayfa Sayıları: ss.350-354

Özet

Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that results in muscle weakness and atrophy. To attenuate disease severity, drug development studies have been applied mainly to target the Survival of Motor Neuron 2 (SMN2) gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level.