Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones

Guner V., Yildirir S., Ozcelik B., Abbasoglu U.

FARMACO, vol.55, no.2, pp.147-150, 2000 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1016/s0014-827x(99)00126-3
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.147-150
  • Hacettepe University Affiliated: Yes

Abstract

Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and H-1 NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested. (C) 2000 Elsevier Science S.A. All rights reserved.