Pregnancy outcomes in partners of male ankylosing spondylitis patients treated with anti-tumour necrosis factor-alpha biologics: real-life results from a single-centre cross-sectional study

UYAROĞLU O. A., ŞEYHOĞLU E., ERDEN A., KILIÇ L., KARADAĞ Ö., AKDOĞAN A., ...Daha Fazla

RHEUMATOLOGY INTERNATIONAL, cilt.40, sa.9, ss.1501-1507, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 9
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00296-020-04518-3
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1501-1507
  • Anahtar Kelimeler: Ankylosing spondylitis, Spondyloarthritis, Tumor necrosis factor-alpha (TNF-alpha) inhibitors, Pregnancy outcomes, Paternal exposure, SPERM CHARACTERISTICS, PATERNAL EXPOSURE, BIRTH OUTCOMES, TNF, METHOTREXATE, ANTAGONISTS, INHIBITORS, INFLIXIMAB, QUALITY, DISEASE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Most patients with inflammatory arthritis are at their reproductive ages. Use of anti-tumour necrosis factor alpha (anti-TNF-alpha) agents, one of the important treatment options for inflammatory arthritis, can cause foetal morbidity and mortality. While most studies on the effects of anti-TNF-alpha agents on pregnancy outcomes are about maternal exposure, the number of studies on the risks related to paternal exposure is insufficient. This study aimed to assess pregnancy periods and outcomes of the partners of male ankylosing spondylitis (AS) patients receiving anti-TNF-alpha treatment during the preconception period. Totally, 163 male AS patients using anti-TNF-alpha agents were identified from the Hacettepe University Biological Registry. Of these patients, 45 (27.6%) who declared that their partners got pregnant after initiation on anti-TNF-alpha agents were included. Data regarding demographics and drug exposure and pregnancy and infant outcomes were evaluated. Of 45 pregnancies, 39 (86.7%) resulted in healthy live births, 3 (6.7%) resulted in spontaneous abortion, and 3 (6.7%) were terminated with curettage. Of 39 live births, 34 (87.2%) were term and 5 (12.8%) were preterm, 30 (76.9%) had normal birth weight, 6 (15.4%) had low birth weight, and 3 (7.7%) had fetal macrosomia. No congenital malformations related to paternal exposure were observed. This study is valuable as being one of the studies providing pregnancy outcomes of partners of male AS patients receiving anti-TNF-alpha agents with its relatively high number of patients. The results suggested that paternal exposure to anti-TNF-alpha agents during preconception period could be safe on pregnancy outcomes.