Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes


Erdogan S., Medarova Z. O. , Roby A., Moore A., Torchilin V. P.

JOURNAL OF MAGNETIC RESONANCE IMAGING, vol.27, no.3, pp.574-580, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1002/jmri.21202
  • Journal Name: JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.574-580
  • Keywords: tumor imaging, MRI, liposome, polychelating, amphihilic polymer, 2C5 antibody, T1 mapping, CONTRAST AGENTS, ANTIBODIES, IDENTIFICATION, DELIVERY, LIGANDS, BINDING
  • Hacettepe University Affiliated: Yes

Abstract

Purpose: To significantly enhance tumor MR imaging by using a contrast agent combining three components-a long-circulating liposome, liposomal membrane-incorporated polychelating amphiphilic polymer heavily loaded with gadolinium, and cancer-specific monoclonal antibody 2C5 attached to the liposome surface.