Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes

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Erdogan S., Medarova Z. O., Roby A., Moore A., Torchilin V. P.

JOURNAL OF MAGNETIC RESONANCE IMAGING, vol.27, no.3, pp.574-580, 2008 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 27 Issue: 3
• Publication Date: 2008
• Doi Number: 10.1002/jmri.21202
• Journal Name: JOURNAL OF MAGNETIC RESONANCE IMAGING
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.574-580
• Keywords: tumor imaging, MRI, liposome, polychelating, amphihilic polymer, 2C5 antibody, T1 mapping, CONTRAST AGENTS, ANTIBODIES, IDENTIFICATION, DELIVERY, LIGANDS, BINDING
• Hacettepe University Affiliated: Yes

Abstract

Purpose: To significantly enhance tumor MR imaging by using a contrast agent combining three components-a long-circulating liposome, liposomal membrane-incorporated polychelating amphiphilic polymer heavily loaded with gadolinium, and cancer-specific monoclonal antibody 2C5 attached to the liposome surface.