Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes


Erdogan S. , Medarova Z. O. , Roby A., Moore A., Torchilin V. P.

JOURNAL OF MAGNETIC RESONANCE IMAGING, cilt.27, ss.574-580, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 27 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/jmri.21202
  • Dergi Adı: JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Sayfa Sayıları: ss.574-580

Özet

Purpose: To significantly enhance tumor MR imaging by using a contrast agent combining three components-a long-circulating liposome, liposomal membrane-incorporated polychelating amphiphilic polymer heavily loaded with gadolinium, and cancer-specific monoclonal antibody 2C5 attached to the liposome surface.