Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes

Erdogan S., Medarova Z. O., Roby A., Moore A., Torchilin V. P.

JOURNAL OF MAGNETIC RESONANCE IMAGING, cilt.27, sa.3, ss.574-580, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/jmri.21202
  • Dergi Adı: JOURNAL OF MAGNETIC RESONANCE IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.574-580
  • Anahtar Kelimeler: tumor imaging, MRI, liposome, polychelating, amphihilic polymer, 2C5 antibody, T1 mapping, CONTRAST AGENTS, ANTIBODIES, IDENTIFICATION, DELIVERY, LIGANDS, BINDING
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: To significantly enhance tumor MR imaging by using a contrast agent combining three components-a long-circulating liposome, liposomal membrane-incorporated polychelating amphiphilic polymer heavily loaded with gadolinium, and cancer-specific monoclonal antibody 2C5 attached to the liposome surface.