Thrombin activatable fibrinolysis inhibitor activity (TAFIa) levels in neonates with meconium-stained amniotic fluid

Gursoy, KADİR; TEKİNALP, GÜLSEVİN; YİĞİT, ŞULE; Kirazli, Serafettin; KORKMAZ TOYGAR, AYŞE; GÜRGEY, AYTEMİZ

doi:10.1080/14767050801891135

Thrombin activatable fibrinolysis inhibitor activity (TAFIa) levels in neonates with meconium-stained amniotic fluid

Atıf İçin Kopyala

Gursoy T., TEKİNALP G., YİĞİT Ş., Kirazli S., KORKMAZ TOYGAR A., GÜRGEY A.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.21, sa.2, ss.123-128, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 2
Basım Tarihi: 2008
Doi Numarası: 10.1080/14767050801891135
Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.123-128
Hacettepe Üniversitesi Adresli: Evet

Özet

Objective.Meconium-stained amniotic fluid (MSAF) is thought to be a sign of fetal hypoxia, which causes activation of coagulation and inhibition of fibrinolysis. Inflammation is also seen in MSAF. On the other hand, thrombin activatable fibrinolysis inhibitor (TAFI) is an inhibitor of fibrinolysis and a regulator of vascular inflammation. For this reason, in this study we aimed to evaluate the relation between hypoxia, fibrinolysis, and inflammation by determining the levels of TAFI activity (TAFIa) in MSAF where inflammation was also thought to have a role in the pathogenesis.