Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plate


COŞKUN S., Korkusuz F., HASIRCI V.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, vol.16, no.12, pp.1485-1502, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1163/156856205774576727
  • Journal Name: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1485-1502
  • Keywords: degradation, PHBV, hydroxyapatite, bone plate, fracture fixation, HYDROXYBUTYRATE HYDROXYVALERATE COPOLYMERS, BIODEGRADABLE MEDICAL DEVICES, L-LACTIDE PLLA, MECHANICAL-PROPERTIES, FRACTURE FIXATION, POLYHYDROXYBUTYRATE COMPOSITE, BIORESORBABLE DEVICES, FORGED COMPOSITES, HA PARTICLES, POLYMERS
  • Hacettepe University Affiliated: Yes

Abstract

Poly(3-hydroxybutyrate) (P3HB), its co-polymers with 3-hydroxyvalerate (HV) (PHBV8 and PHBV22), and their hydroxyapatite (HAp) containing composites (5 and 15%, w/w) were prepared by injection molding. PHBV bone plates with low valerate contents and 15% (w/w) HAp appear to have better mechanical properties than the others. Flexural strengths of 15% (w/w) HAp-loaded P3HB, PHBV8 and PHBV22 were 78.28, 63.45 and 39.38 MPa, respectively. Tensile strengths of 15% (w/w) HAp-loaded P3HB, PHBV8 and PHBV22 were 18.99, 15.44 and 11.02 Wa, respectively. For the ageing test, bone plates were incubated in phosphate-buffered saline PBS (0.1 M, pH 7.4) at 37 degrees C and at pre-determined time points they were removed and subjected to a three-point bending test. Incubation in PBS caused a sharp decrease in the mechanical properties within the first 24 h, followed either by a gradual decrease or no change for a period of about 1 month. SEM results showed that there was no significant material erosion in the 4-week incubation period. P3HB loaded with 15% HAp appeared to yield the most suitable bone plate, insofar as mechanical properties are concerned with potential for further testing in vivo.