Akademik Veri Yönetim Sistemi
Advances in Microscale Electro- and Liquid Phase-Based Separation Techniques, Elsevier, ss.799-829, 2026
Microfabricated lab-on-a-chip systems, which are decreasing in size, require increased detection sensitivity due to reduced sample volumes. The portability of electrophoresis-based microfluidics facilitates rapid, sequential sample analysis, challenging the traditional advantages of liquid chromatography. Additionally, the integration of microfluidic systems with detection methods, such as electrospray mass spectrometry, polymerase chain reaction, and gas chromatography-mass spectrometry, accelerates analysis speed and accuracy while minimizing sample and eluent usage. Dielectrophoretic and electrophoretic techniques allow better manipulation and separation of both charged and uncharged particles, making significant advancements in research and industrial applications. This chapter explores the ongoing advancements in miniaturized liquid chromatography based on electrophoresis, including microchip capillary electrophoresis and capillary electrochromatography systems, which are driving the development of portable, high-efficiency separation techniques. Recent developments in creating more compact, automated, and energy-efficient systems that address current limitations and enhance on-site analysis capabilities are reviewed.