Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis


Kekilli M., Tunc B., Beyazit Y., Kurt M., Onal I. K. , Ulker A., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.58, sa.5, ss.1250-1255, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Konu: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10620-012-2511-y
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Sayfa Sayıları: ss.1250-1255

Özet

Immunopathogenetic features of primary sclerosing cholangitis (PSC) in ulcerative colitis (UC) still remains unclear. Peripheral blood CD4+CD25+ regulatory T cells have a key role in the induction and maintenance of peripheral self-tolerance and inhibit several organ-specific autoimmune diseases. Therefore, CD4+CD25+ T cells are believed to play an essential role in autoimmune diseases. The aim of the present study is to analyze the role of CD4+CD25+ T cells in the pathogenesis of UC-associated PSC.