Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis

Kekilli, Murat; Tunc, Bilge; Beyazit, Yavuz; Kurt, Mevlut; Onal, Ibrahim; Ulker, Aysel; HAZNEDAROĞLU, İBRAHİM

doi:10.1007/s10620-012-2511-y

Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis

Kekilli M., Tunc B., Beyazit Y., Kurt M., Onal I. K., Ulker A., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.58, sa.5, ss.1250-1255, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 58 Sayı: 5
Basım Tarihi: 2013
Doi Numarası: 10.1007/s10620-012-2511-y
Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1250-1255
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

Immunopathogenetic features of primary sclerosing cholangitis (PSC) in ulcerative colitis (UC) still remains unclear. Peripheral blood CD4+CD25+ regulatory T cells have a key role in the induction and maintenance of peripheral self-tolerance and inhibit several organ-specific autoimmune diseases. Therefore, CD4+CD25+ T cells are believed to play an essential role in autoimmune diseases. The aim of the present study is to analyze the role of CD4+CD25+ T cells in the pathogenesis of UC-associated PSC.