Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis

Kekilli, Murat; Tunc, Bilge; Beyazit, Yavuz; Kurt, Mevlut; Onal, Ibrahim; Ulker, Aysel; HAZNEDAROĞLU, İBRAHİM

doi:10.1007/s10620-012-2511-y

Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis

Kekilli M., Tunc B., Beyazit Y., Kurt M., Onal I. K., Ulker A., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.58, no.5, pp.1250-1255, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 58 Issue: 5
Publication Date: 2013
Doi Number: 10.1007/s10620-012-2511-y
Journal Name: DIGESTIVE DISEASES AND SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1250-1255
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Immunopathogenetic features of primary sclerosing cholangitis (PSC) in ulcerative colitis (UC) still remains unclear. Peripheral blood CD4+CD25+ regulatory T cells have a key role in the induction and maintenance of peripheral self-tolerance and inhibit several organ-specific autoimmune diseases. Therefore, CD4+CD25+ T cells are believed to play an essential role in autoimmune diseases. The aim of the present study is to analyze the role of CD4+CD25+ T cells in the pathogenesis of UC-associated PSC.