Synthesis and biological activities of some thiazolidin-4-ones

Ozadah K., Ozkanh F., Erol D., Dogan A. E., Erol K.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.56, no.10, pp.678-681, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 10
  • Publication Date: 2006
  • Doi Number: 10.1055/s-0031-1296772
  • Journal Name: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.678-681
  • Hacettepe University Affiliated: Yes

Abstract

In this study, 15 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and α-mercaptoacetic acid. The structures of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectral data and elementary analysis. The antihistaminic and anticholinergic activities of the compounds determined by the tests performed on isolated guinea pig trachea in comparison with aminophilline (CAS number: 317-34-0). Compound 15, 3-[3-(2-methylpiperidine-1-yl)propyl]-2-(4-methylphenyl)thiazolidin-4-one hydrochloride, the highest inhibition (53 %).

In this study, fifteen 2,3-disubstituted-4-thiazolidinone derivatives were synthesized by the reaction of Schiff bases and a-mercaptoacetic acid. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, mass spectral data and elementary analysis. The antihist-aminic and anticholinergic activities of the compounds were determined by tests performed on isolated guinea pig trachea in comparison with aminophylline (CAS 317-34-0). Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl- phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53%).