Proton pump inhibitor omeprazole use is associated with low bone mineral density in maintenance haemodialysis patients

Kirkpantur, A.; Altun, B.; Arici, M.; Turgan, C.

doi:10.1111/j.1742-1241.2008.01883.x

Proton pump inhibitor omeprazole use is associated with low bone mineral density in maintenance haemodialysis patients

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Kirkpantur A., Altun B., Arici M., Turgan C.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.63, no.2, pp.261-268, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 63 Issue: 2
Publication Date: 2009
Doi Number: 10.1111/j.1742-1241.2008.01883.x
Journal Name: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.261-268
Hacettepe University Affiliated: Yes

Abstract

Limited studies have shown that proton pump inhibitor (PPI) therapy may decrease bone density or insoluble calcium reabsorption through induction of hypochlorhydria. However, PPI therapy may also reduce bone resorption via inhibition of osteoclastic vacuolar proton pumps. The aim of this study was to determine whether the opposing effects of PPI therapy may cause clinically important alterations in bone mineral densitometry (BMD) parameters in maintenance haemodialysis patients.