Proton pump inhibitor omeprazole use is associated with low bone mineral density in maintenance haemodialysis patients

Kirkpantur, A.; Altun, B.; Arici, M.; Turgan, C.

doi:10.1111/j.1742-1241.2008.01883.x

Proton pump inhibitor omeprazole use is associated with low bone mineral density in maintenance haemodialysis patients

Kirkpantur A., Altun B., Arici M., Turgan C.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, cilt.63, sa.2, ss.261-268, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 63 Sayı: 2
Basım Tarihi: 2009
Doi Numarası: 10.1111/j.1742-1241.2008.01883.x
Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.261-268
Hacettepe Üniversitesi Adresli: Evet

Özet

Limited studies have shown that proton pump inhibitor (PPI) therapy may decrease bone density or insoluble calcium reabsorption through induction of hypochlorhydria. However, PPI therapy may also reduce bone resorption via inhibition of osteoclastic vacuolar proton pumps. The aim of this study was to determine whether the opposing effects of PPI therapy may cause clinically important alterations in bone mineral densitometry (BMD) parameters in maintenance haemodialysis patients.