Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits


Seckin H., Yigitkanli K., Besalti O., KÖSEMEHMETOĞLU K. , Ozturk E., Simsek S., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.70, ss.344-351, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 70 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.surneu.2007.07.052
  • Dergi Adı: SURGICAL NEUROLOGY
  • Sayfa Sayıları: ss.344-351

Özet

Background: Increasing evidence implicates voltage-dependent sodium and potassium channels, in addition to calcium channels of various types, in the pathophysiological development of cerebral vasospasm. This study investigated the ability of LTG, an antiepileptic drug with multi-ion channel inhibition properties, to prevent cerebral vasospasm and subsequent neural ischemia in a rabbit model of SAH.