Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits

Seckin H., Yigitkanli K., Besalti O., KÖSEMEHMETOĞLU K., Ozturk E., Simsek S., ...More

SURGICAL NEUROLOGY, vol.70, no.4, pp.344-351, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1016/j.surneu.2007.07.052
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.344-351
  • Hacettepe University Affiliated: Yes


Background: Increasing evidence implicates voltage-dependent sodium and potassium channels, in addition to calcium channels of various types, in the pathophysiological development of cerebral vasospasm. This study investigated the ability of LTG, an antiepileptic drug with multi-ion channel inhibition properties, to prevent cerebral vasospasm and subsequent neural ischemia in a rabbit model of SAH.