Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis

Ozturk E., Surucu M., Karaman A., ŞAMDANCI E., FADILLIOĞLU E.

JOURNAL OF SURGICAL RESEARCH, vol.187, no.2, pp.610-615, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 187 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jss.2013.11.005
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.610-615
  • Hacettepe University Affiliated: Yes


Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.