Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis
JOURNAL OF SURGICAL RESEARCH, vol.187, no.2, pp.610-615, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 187 Issue: 2
- Publication Date: 2014
- Doi Number: 10.1016/j.jss.2013.11.005
- Journal Name: JOURNAL OF SURGICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.610-615
- Hacettepe University Affiliated: Yes
Abstract
Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.