Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis
JOURNAL OF SURGICAL RESEARCH, cilt.187, sa.2, ss.610-615, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 187 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.1016/j.jss.2013.11.005
- Dergi Adı: JOURNAL OF SURGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.610-615
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.