The effect of age on proliferating cell nuclear antigen expression in oral gingival epithelium of healthy and inflamed human gingiva

Celenligil-Nazliel H., Ayhan A., Uzun H., Ruacan S.

JOURNAL OF PERIODONTOLOGY, vol.71, no.10, pp.1567-1574, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 10
  • Publication Date: 2000
  • Doi Number: 10.1902/jop.2000.71.10.1567
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1567-1574
  • Hacettepe University Affiliated: No


Background: Age-related changes in proliferative activity in human gingival epithelium are uncertain. Proliferating cell nuclear antigen (PCNA) is a nuclear protein associated with the cell cycle. Nuclear PCNA immunoreactivity is found in the proliferative compartment of normal tissues. The aims of this study were to investigate the localization of PCNA expression in oral gingival epithelium (OGE) and to define the age-related changes as to PCNA-proliferative index (PI) in inflamed as well as healthy gingiva. Mitotic index (MI) was also used as a conventional marker of cell proliferation. Additionally, the effect of aging upon the maximum epithelial thickness (MET) was determined.