Insulin resistance in polycystic ovary syndrome: Maker or marker?

BOZDAĞ G., YILDIZ B.

Expert Review of Obstetrics and Gynecology, cilt.5, sa.1, ss.67-75, 2010 (AHCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1586/eog.09.73
  • Dergi Adı: Expert Review of Obstetrics and Gynecology
  • Derginin Tarandığı İndeksler: Arts and Humanities Citation Index (AHCI)
  • Sayfa Sayıları: ss.67-75
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Insulin resistance plays a central role in the pathophysiology of polycystic ovary syndrome (PCOS). However, this finding is not universal in PCOS, and many women with insulin resistance do not develop this syndrome, leading to much controversy. Insulin resistance is more prevalent in certain phenotypes of PCOS, but tests of insulin resistance are not included in any of the currently used diagnostic criteria to define PCOS. Several genetic and environmental factors and their interactions appear to modulate the presence, degree and expression of insulin resistance. Tissue-specific defects in insulin signaling have been described, and different tissues contribute to insulin resistance differently in PCOS. Our understanding of the syndrome may benefit from greater insight into the mechanisms of the complex inter-relationship between insulin resistance and PCOS. © 2010 Expert Reviews Ltd.