Effect of X-Ray Irradiation on Some Analgesics, Anti-Diabetics, PPI'S, Anti-Hypertensives, Heart Failure Drugs in Tablet and Capsule Forms


SARCAN E. T., Tas A., SİLİNDİR GÜNAY M., ÖZER A. Y., PALASKA E., Hekimoglu B.

JOURNAL OF PHARMACEUTICAL SCIENCES, vol.109, no.12, pp.3653-3659, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 109 Issue: 12
  • Publication Date: 2020
  • Doi Number: 10.1016/j.xphs.2020.09.028
  • Journal Name: JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Analytical Abstracts, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.3653-3659
  • Keywords: X-ray, DSC/TGA, FT-IR, Analgesics, Anti-diabetics, Proton pump inhibitors, Heart failure drugs, Anti-hypertensives, GAMMA-RADIATION, SPECTROPHOTOMETRIC METHOD, AQUEOUS-SOLUTIONS, EXPOSURE
  • Hacettepe University Affiliated: Yes

Abstract

X-ray is an ionizing-radiation and it has been used in many processes due to the developing technology. For security purposes, X-ray instruments are been using at the entrance of the airports, shopping centers, etc. In this study, potential effects of X-ray were investigated on five different types of drugs: analgesics (acetaminophen, acetylsalicylic acid, naproxen, flurbiprofen), proton pump inhibitors (lansoprazole, pantoprazole sodium sesquihydrate), anti-diabetics (metformin HCl, pioglitazone), heart failure drugs (verapamil HCl, spironolactone) and anti-hypertensives (losartan, clopidogrel hydrogen sulphate) by several different methods.