Serum YKL-40 as a Marker of Left Atrial Fibrosis Assessed by Delayed Enhancement MRI in Lone Atrial Fibrillation

CANPOLAT U., AYTEMİR K., HAZIROLAN T., ÖZER N., Oto A.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, vol.38, no.12, pp.1386-1395, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1111/pace.12729
  • Journal Name: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1386-1395
  • Keywords: atrial fibrillation, YKL-40, magnetic resonance imaging, atrial fibrosis, CATHETER ABLATION, ASSOCIATION, SUBSTRATE, BIOMARKER, DISEASE
  • Hacettepe University Affiliated: Yes

Abstract

Background: Assessment of the left atrial (LA) fibrosis by using delayed-enhanced magnetic resonance imaging (DE-MRI) in atrial fibrillation (AF) patients is a pioneering noninvasive method. Serum YKL-40 is a novel marker for inflammation and known to play a role in ongoing tissue fibrosis. However, its role in LA fibrosis is unclear. We aimed to investigate the association of serum YKL-40 with the presence and extent of LA fibrosis.