Serum YKL-40 as a Marker of Left Atrial Fibrosis Assessed by Delayed Enhancement MRI in Lone Atrial Fibrillation

CANPOLAT U., AYTEMİR K., HAZIROLAN T., ÖZER N., Oto A.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, cilt.38, sa.12, ss.1386-1395, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/pace.12729
  • Dergi Adı: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1386-1395
  • Anahtar Kelimeler: atrial fibrillation, YKL-40, magnetic resonance imaging, atrial fibrosis, CATHETER ABLATION, ASSOCIATION, SUBSTRATE, BIOMARKER, DISEASE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Assessment of the left atrial (LA) fibrosis by using delayed-enhanced magnetic resonance imaging (DE-MRI) in atrial fibrillation (AF) patients is a pioneering noninvasive method. Serum YKL-40 is a novel marker for inflammation and known to play a role in ongoing tissue fibrosis. However, its role in LA fibrosis is unclear. We aimed to investigate the association of serum YKL-40 with the presence and extent of LA fibrosis.