The Selective Expression of Ret Finger Protein in Endometrial Cancer: Can RFP be a Marker of Serous Carcinomas?

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Tezel G. G., Ordulu Z., Himmetoglu C., USUBÜTÜN A.

TURKISH JOURNAL OF PATHOLOGY, vol.28, no.3, pp.213-219, 2012 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.5146/tjpath.2012.01127
  • Journal Name: TURKISH JOURNAL OF PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-219
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Endometrial cancer is a common malignancy of the gynecological system and has been classified into two major groups, Types I and II. Type I tumors are estrogen-related, low-grade endometrioid tumors, whereas type II tumors are aggressive, high-grade non-endometrioid tumors. Ret finger protein is a nuclear transcription factor with a tripartite motif that is highly expressed in different tumor cells.