The Selective Expression of Ret Finger Protein in Endometrial Cancer: Can RFP be a Marker of Serous Carcinomas?

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Tezel G. G., Ordulu Z., Himmetoglu C., USUBÜTÜN A.

TURKISH JOURNAL OF PATHOLOGY, cilt.28, sa.3, ss.213-219, 2012 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5146/tjpath.2012.01127
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-219
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Endometrial cancer is a common malignancy of the gynecological system and has been classified into two major groups, Types I and II. Type I tumors are estrogen-related, low-grade endometrioid tumors, whereas type II tumors are aggressive, high-grade non-endometrioid tumors. Ret finger protein is a nuclear transcription factor with a tripartite motif that is highly expressed in different tumor cells.