ALLELE FREQUENCIES OF MP6D-9 AND GATT MARKERS IN 32 TURKISH CYSTIC-FIBROSIS FAMILIES

OZGUC, M; YILMAZ, E; ERDEM, H; COSKUN, T; ÖZÇELİK, HAYRİYE; TOGAN, I; GOCMEN, A; AYTER, S; OZALP, I

doi:10.1111/j.1399-0004.1994.tb04153.x

ALLELE FREQUENCIES OF MP6D-9 AND GATT MARKERS IN 32 TURKISH CYSTIC-FIBROSIS FAMILIES

OZGUC M., YILMAZ E., ERDEM H., COSKUN T., ÖZÇELİK H. U., TOGAN I., ...Daha Fazla

CLINICAL GENETICS, cilt.45, sa.5, ss.266-268, 1994 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 5
Basım Tarihi: 1994
Doi Numarası: 10.1111/j.1399-0004.1994.tb04153.x
Dergi Adı: CLINICAL GENETICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.266-268
Anahtar Kelimeler: CYSTIC FIBROSIS, GATT, MP6D-9, LINKAGE DISEQUILIBRIUM, DELTA-F508 MUTATION, GENE, DNA, CHROMOSOMES, HAPLOTYPES, POPULATION, REPEAT, LOCUS, XV-2C
Hacettepe Üniversitesi Adresli: Hayır

Özet

The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the DELTAF508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.