Plasma 8-isoPGF2 alpha and serum melatonin levels in patients with minimal cognitive impairment and Alzheimer disease


Sirin F. B. , KUMBUL DOĞUÇ D., Vural H., Eren I., Inanli I., Sutcu R., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1073-1077, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1406-134
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1073-1077

Abstract

Background/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not.